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KMID : 0380620220540050483
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 5 p.483 ~ p.489
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Effects of dietary carotenoid pigments on growth and inflammatory responses in skin cells and monocytes
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Lee Eun-Bin
Hong Jung-Il
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Abstract
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Carotenoids have shown various beneficial health effects in humans. In this study, the effects of dietary carotenoids, including norbixin (annatto), bixin, crocin, and lutein, on skin cell proliferation and inflammation, and monocyte differentiation were investigated. None of the carotenoids affected the growth of human keratinocyte (HaCaT) during 24 h, whereas annatto and bixin stimulated proliferation of human dermal fibroblast (HDF). Long-term treatment (7 d) of annatto and bixin inhibited keratinocyte growth, whereas lutein enhanced keratinocyte growth. All carotenoids, except lutein, decreased mRNA levels of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-8, in phorbol-12-myristate-13-acetate (PMA)-stimulated keratinocytes. However, bixin and lutein inhibited PMA-induced HaCaT growth. Monocyte (THP-1) differentiation induced by PMA was also inhibited by the carotenoids, and lutein showed the strongest inhibitory effect. These results suggest that carotenoids modulate the proliferation and inflammatory responses of skin cells and monocytes.
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KEYWORD
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carotenoids, keratinocytes, monocytes, annatto, lutein, skin inflammation
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